Cuff pressure algometry is a novel method for quantitative, objective pain assessment that enables a mechanism-based quantification of pain sensitivity. The mechanistic approach can identify pain mechanisms related to the peripheral or central nervous system.

Cuff pressure algometry uses computer controlled cuffs that are inflated on the test subject’ arms or legs to induce pressure pain while the subject rates the sensation on a user-defined Visual Analog Scale (VAS).

Well-defined and precisely delivered pressure stimulations will be performed by the device. This enables the experimenter to employ protocols that assess the subjects’ stimulus response to pressure, temporal and spatial summation as well as conditioned pain modulation (CPM).

Benefits

CLINICALLY RELEVANT DATA

    • Assesses deep tissue pain as opposed to cutaneous pain assessed by conventional handheld pressure algometry

AUTOMATE YOUR EXPERIMENTS

    • Pre-defined experimental protocols that automates execution of experiments that eliminates experimenter bias

FASTER DATA ANALYSIS

    Data is automatically saved in formats that enable easy analysis in programs such as Excel, Matlab, or SPSS.

COMPUTER CONTROLLED

    • Computer controlled pressure stimulation enabling well-defined, precise stimulus-response curves, temporal and spatial summation, and conditioned pain modulation

KEEP TRACK OF YOUR EXPERIMENTS

    Automatic logging of all events relevant for the analysis of experimental data.

Experimental Protocol

STIMULUS-RESPONSE

A stimulus-dependent protocol in which the pressure is linearly increased while the subject rates the pain or stops the stimulation. From these stimulus response curves the system can automatically calculate pain detection thresholds (PDT), pain tolerance threshold (PTT), as well as the pressure required to elicit a given VAS score from the subject.

This test reflects the general pain sensitivity.

TEMPORAL SUMMATION

A response-dependent protocol in which pressure stimuli of the same intensity (typically the individual PTT) is applied repetitively while the subjects rates the pain sensation. Temporal summation is then determined based on the subjects’ individual pain responds to the stimuli. Standard and evidence-based protocols are available or protocols can be tailored to a specific research project.

This test reflects the degree of cuff induced temporal summation, which has been demonstrated to be unregulated in various chronic pain conditions.

SPATIAL SUMMATION

Spatial summation can be performed both with response-dependent and stimulus-dependent protocols. With spatial summation the same protocol (e.g. PDT/PTT) is performed repeatedly with two cuffs with a different surface stimulation area (or two equally sized cuffs placed as next to each other).

This test will add additional information as it reflects the degree or cuff induced spatial summation

CONDITIONED PAIN MODULATION

Conditioned pain modulation is performed using two cuffs at two different body sites. One cuff is inflated to a constant painful or non-painful pressure stimulation, while the other is used to determine a stimulus-response curve.

The cuff conditioning pain modulation protocol is used for assessment of the descending pain control system.